Ulcerative colitis (UC) is a type of colitis, and its disease is caused by immune factors, genetic factors, environmental factors and infectious factors. Recent studies have found that the combination of probiotics and prebiotics can effectively relieve UC inflammation. Recently, Peng Nan and his team from Chengdu University/Huazhong Agricultural University published a new study in Microbiology spectrum, using DSS induction to construct a mouse colitis model, and found that the combination of Bacillus coagulans FCYS01 spores and chitosan oligosaccharides can significantly alleviate DSS induced UC, and the therapeutic effect is better than that of the two alone. In conclusion, this study provides a new idea for the future use of probiotics and prebiotics to intervene in colitis.
To evaluate the therapeutic effect of Bacillus coagulans FCYS01 spores on DSS induced ulcerative colitis (UC) in mice with and without chitooligosaccharides (COSs);
Supplementation of FCYS01, COSs or the combination of the two can reduce tissue injury, regulate the levels of cytokines and C-reactive protein, increase the expression of tight junction protein and mucin, promote the restoration of intestinal barrier and effectively alleviate UC;
Supplementation of FCYS01 and COSs can also regulate the composition of intestinal flora, increase the abundance of short-chain fatty acid producing bacteria such as Ackermannia and ruminococcus, and improve the level of short-chain fatty acid;
The combination of FCYS01 spores and COSs can significantly relieve DSS induced UC, and the therapeutic effect is better than that of the two alone
10.1128/spectrum.00641-22
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