Liver diseases are associated with many factors, including medicines and alcoholics, which have become a global problem. It is crucial to overcome this problem. Liver diseases always come with inflammatory complications, which might be a potential target to deal with this issue.Alginate oligosaccharides (AOS) have been demonstrated to have many benefificial effects, especially anti-inflflammation.Researcher used busulfan to establish the liver injury model in the current study, They found that AOS 10 mg/kg could ameliorate the liver structure disrupted by busulfan, based on TEM ultrastructural pathological analysis. They discovered that busulfan-induced loosely arranged hepatocytes, dilated hepatic sinuses, and abnormal mitochondrial physiological structure, while AOS could improve busulfan-induced liver damage signifificantly. Furthermore, RNAseq analysis determined that AOS 10 mg/kg could improve the expressions of genes related to liver function. The RNA-seq data alao suggest that AOS 10 mg/kg may repair busulfan-induced liver damage by suppressing the inflammation-related signal pathway.In addition,AOS could improve the systemic environment to ameliorate busulfan-caused liverdamage.These data confirm that AOS protects hepatic health.
The study presents a new idea for treating liver disease, especially with inflammation complications. As a natural product with many physical benefifits and no side effects, AOS is a potential therapeutic method to boost liver function for patients with liver diseases. We have reason to believe that AOS and even its derivatives will be widely used in our life and play important roles widely. The underlying mechanisms of AOS are attracting more and more attention.
Reference:Alginate Oligosaccharides Repair Liver Injury by Improving
Anti-Inflflammatory Capacity in a Busulfan-Induced Mouse Model
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