Chitosan oligosaccharides are a new class of non-toxic, low-cost, small-molecule natural anti-inflammatory products. Using lipopolysaccharide-stimulated Caco-2 cells as an IBD model to study the effects of chitosan oligosaccharide on inflammation and apoptosis of intestinal epithelial cells.
Studies have shown that chitosan oligosaccharide can inhibit lipopolysaccharide-induced intestinal epithelial cell inflammation and apoptosis, and the anti-inflammatory effect is positively correlated with the concentration of chitosan oligosaccharide within a certain range. Studies suggest that chitooligosaccharide treatment can significantly reduce the expression of TLR4 and NF-κB proteins in lipopolysaccharide-stimulated intestinal epithelial cells, which may play a potential medical role in the control of intestinal inflammation in this way.
Note: The chitosan oligosaccharides used in the experiment were from Qingdao BZ Oligo Biotech Co., Ltd.
From "Chitooligosaccharides Attenuate Lipopolysaccharide-induced Inflammation and Apoptosis of Intestinal Epithelial Cells: Possible Involvement of TLR4/NF-κB Pathway"
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