Agarose oligosaccharides isolated from red algae have various biological functions and activities, including antibacterial, anti-inflammatory and antioxidant. Studies have shown that agar-oligosaccharide has a potential protective effect on 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells and can reduce nerve damage. The main neuroprotective monomer in agarose oligosaccharide is agaropentose (AOP).
Agar oligosaccharide plays a major role in inhibiting nerve injury: AOP can reduce the production of ROS, cause mitochondrial dysfunction, inhibit the activation of downstream signaling molecules Bax, p38MAPK, Caspase-3 and NF-κB, thereby enhancing the viability of SH-SY5Y cells .
Note: The series of agarose oligosaccharide reference substances used in this test are from our company, Qingdao BZ Oligo Biotech Co., Ltd.
Agar oligosaccharide can be used as a new functional food additive or neurological disease therapeutic agent, and AOP has great potential to be developed as a functional drug for the treatment of some neurodegenerative diseases.
Excerpted from "Agaropentaose protects SH-SY5Y cells against 6-hydroxydopamine-induced neurotoxicity through modulating NF-κB and p38MAPK signaling pathways"
Disclaimer: The contents of the above reprinted or quoted articles are only used for learning and research purposes. If there is any discrepancy, please correct it immediately.