Diabetic foot is a diabetic complication caused by hyperglycemia causing inflammation at the wound site. It is also a difficult problem that has not yet been solved in medicine. Therefore, the design and development of a kind of dressing with immunomodulatory activity and help for chronic inflammation is one of the effective and feasible solutions.
κ/β-carrageenan oligosaccharide (L-DS-KOS) can stimulate M1-type RAW264.7 macrophages to massively secrete anti-inflammatory factors interleukin (IL)-10 and transforming growth factor (TGF)-β2 while reducing pro-inflammatory factors Secretion of IL-6 and tumor necrosis factor (TNF)-α. The general observation of the repair of full-thickness defects in diabetic rats shows that the sponge dressing with L-DS-KOS/collagen ratio of 3:7 can effectively accelerate wound healing. It can be seen by H&E and Masson staining that it can better shorten the wound. The inflammatory phase of the site, and improve the process of collagen deposition and epithelialization, thereby promoting skin wound repair in diabetic rats. Considering that it can effectively regulate the secretion of immune factors and accelerate the transformation of macrophage phenotype from M1 to M2, thereby improving the special long-term inflammatory microenvironment of diabetic wounds, we believe that it is expected to be used as a new type of immunomodulatory active material for Design of diabetic wound dressings.
The article is derived from "Immune regulatory activity of κ/β-carrageenan oligosaccharide on macrophages and its use in diabetic skin repair"
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