Alginate oligosaccharide (AOS) is a oligomeric sugar containing 2~25 sugar units obtained from alginate through glycosidic bond cleavage or its monosaccharide component through biosynthesis/organic synthesis. function. Due to its low molecular weight, high water solubility, safety and non-toxicity, etc., it has received great attention from researchers in recent years. There are new breakthroughs in the mechanism of action of Alginate oligosaccharide in the intestine. This article briefly outlines it for the majority of friends to learn and think about.
1. Relieve intestinal mucosal inflammation
In 2020, the research team of livestock nutrition and regulation science and technology innovation team of Beijing Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences revealed that Alginate Oligosaccharide has the mechanism of relieving small intestinal mucosal inflammation and promoting intestinal health. The research results were published online in Mucosal Immunology IF 6.7.
In this study, busulfan was used to construct an intestinal mucositis model. Using single-cell RNA sequencing and functional enrichment analysis, it was found that the mechanism of action of Alginate Oligosaccharide is as follows:
Step 1. Regulate gene expression disturbed by busulfan Alginate Oligosaccharide can regulate the gene expression disturbed by busulfan, alleviate the damage to the endoplasmic reticulum, mitochondria, cell membrane, intercellular junctions and microvilli in mouse intestinal cells, maintain the normal function of cells, and then reduce the inflammatory damage of the small intestinal mucosa;
Step 2. Mannose receptor signaling pathway PEC-J2 cell assay further revealed that Alginate Oligosaccharide acts on intestinal cells through the mannose receptor signaling pathway;
Step 3. Promote the recovery of intestinal epithelial cells The analysis of blood metabolome and gut microbial community further confirmed that Alginate Oligosaccharide can improve small intestinal tuft cells, goblet cells and Paneth cells, and promote the recovery of intestinal epithelial cells, thereby improving the healthy function of the small intestine.
2. Regulate receptor gut microbiota
Also in 2020, an article published in "Microbiome IF: 11.6" conducted research using fecal microbiota transplantation in mice. The results showed that compared with the fecal microbiota transplantation of control mice, the Fecal microbiota transplantation in mice supplemented with Alginate Oligosaccharide doses improved small intestinal function in mice by restoring gene expression and increasing junctional protein levels, thereby alleviating small intestinal mucosal inflammation.
Beneficial for the gut microbiome
Fecal microbiota transplantation in mice with Alginate Oligosaccharide doses had greater benefits for recipient gut microbes than in control mice, by increasing beneficial microbes such as Leucoidellaceae and restoring blood metabolomes while reducing The "harmful" bacteria Desulfovibrioideae.
Recovery of blood metabolites
The correlation of gut microbiota with blood metabolites suggests that the beneficial microorganism Lactobacillus contributes to the recovery of blood metabolites, whereas the harmful microorganism Mycoplasma does not.
To sum up
In recent years, Alginate Oligosaccharide has become a research hotspot, and its potential value has been gradually excavated. Therefore, we determined that Alginate Oligosaccharide, as a prebiotic, has the functions of promoting the recovery of intestinal epithelial cells and improving the intestinal microbiota, and can be used to prevent and relieve the intestinal mucosa of livestock and poultry. inflammation, improve the healthy function of the small intestine, etc.
References
[1] Zhao Y , Feng Y , Liu M , et al. Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis[J]. Mucosal Immunology, 2020, 13(3):1-12.
[2] Zhang P , Liu J , Xiong B , et al. Microbiota from alginate oligosaccharide-dosed mice successfully mitigated small intestinal mucositis[J]. Microbiome, 2020, 8(1).
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