Inflammatory bowel disease (IBD) is a multifactorial disorder characterized by chronic and recurrent episodes of inflammation in specifific segments of the intestine. IBD can be instigated by both genetic and environmental factors, but the rise in IBD cases over the last decade suggests the decisive role of diverse environmental factors in the pathogenesis of IBD . Diet is an important environmental factor that can be an alternative to drugs, since components such as prebiotics are known to regulate intestinal inflflammation by maintaining immune homeostasis. These non-digestible carbohydrates are considered as establishers of benefificial bacteria that can produce bioactive metabolites, such as short-chain fatty acids that provide energy to enterocytes and maintain mucosal integrity .
Alginate oligosaccharides (AOS) are natural bioactive compounds and among other bioactivities have anti-inflammatory, antioxidant and prebiotic properties .We employed an adult zebrafish intestine inflammation model to understand the efficacy of the macroalgaderived oligosaccharides to counter inflammation. In addition, we investigated the changes caused by AOS and those imparted by a well-known anti-inflammatory product, algal β-(1, 3)-glucan .
The experiment result shows that dietary AOS with a higher percentage of low molecular weight reduced the expression of several inflammatory marker genes, increased goblet cell number, villi height and a SCFA in the plasma. The BG diet suppressed several immune genes linked to the endopeptidase activity and proteolysis, suggesting a possible role of algal b-glucan in controlling the tissue damage caused by dietary soybean. In the future, it would be interesting to study the impact of structurally different AOS on the microbiota composition and SCFAs in zebrafish and explore the synergetic effect of AOS and algalβ-glucan in reducing soybean induced intestinal inflammation.
Reference:Potential of algae-derived alginate oligosaccharides and b-glucan to counter inflammation in adult zebrafish intestineInflammatory bowel disease (IBD) is a multifactorial disorder characterized by chronic and recurrent episodes of inflammation in specifific segments of the intestine. IBD can be instigated by both genetic and environmental factors, but the rise in IBD cases over the last decade suggests the decisive role of diverse environmental factors in the pathogenesis of IBD . Diet is an important environmental factor that can be an alternative to drugs, since components such as prebiotics are known to regulate intestinal inflflammation by maintaining immune homeostasis. These non-digestible carbohydrates are considered as establishers of benefificial bacteria that can produce bioactive metabolites, such as short-chain fatty acids that provide energy to enterocytes and maintain mucosal integrity .
Alginate oligosaccharides (AOS) are natural bioactive compounds and among other bioactivities have anti-inflammatory, antioxidant and prebiotic properties .We employed an adult zebrafish intestine inflammation model to understand the efficacy of the macroalgaderived oligosaccharides to counter inflammation. In addition, we investigated the changes caused by AOS and those imparted by a well-known anti-inflammatory product, algal β-(1, 3)-glucan .
The experiment result shows that dietary AOS with a higher percentage of low molecular weight reduced the expression of several inflammatory marker genes, increased goblet cell number, villi height and a SCFA in the plasma. The BG diet suppressed several immune genes linked to the endopeptidase activity and proteolysis, suggesting a possible role of algal b-glucan in controlling the tissue damage caused by dietary soybean. In the future, it would be interesting to study the impact of structurally different AOS on the microbiota composition and SCFAs in zebrafish and explore the synergetic effect of AOS and algalβ-glucan in reducing soybean induced intestinal inflammation.
Reference:Potential of algae-derived alginate oligosaccharides and b-glucan to counter inflammation in adult zebrafish intestine
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